- Product Name Busulfan
- cas 55-98-1
- purity 99%
Pharmaceutical
Quality products?make an important contribution to long-term revenue and profitability. Factory Supply industrial standard Busulfan 55-98-1 In Stock
1.What is the Busulfan ?
Busulfan (Myleran) is a bifunctional methanesulfonic ester that forms intrastrand cross-linkages with DNA. The drug is well absorbed after oral administration and has a plasma half-life of less than 5 minutes. Metabolites and degradation products are excreted primarily in the urine. Busulfan is used in the palliative treatment of chronic granulocytic leukemia. Daily oral therapy results in decreased peripheral white blood cells and improved symptoms in almost all patients during the chronic phase of the disease. Excessive uric acid production from rapid tumor cell lysis should be prevented by coadministration of allopurinol. At usual therapeutic dosages, busulfan is selectively toxic to granulocyte precursors rather than lymphocytes. Thrombocytopenia and anemia and less commonly, nausea, alopecia, mucositis, and sterility also may occur. Unusual side effects of busulfan include gynecomastia, a general increase in skin pigmentation, and interstitial pulmonary fibrosis.
Busulfan USP (Myleran) is used to treat Chronic granulocytic leukemia; other myeloproliferative disorders.
-
-
110-63-4
Butane-1,4-diol
-
-
124-63-0
methanesulfonyl chloride
-
-
55-98-1
busulfan
Conditions
| Conditions | Yield |
|---|---|
|
With
triethylamine;
In
dichloromethane;
at 10 - 20 ℃;
for 24h;
|
86%
|
|
With
triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 4h;
|
73.52%
|
|
With
pyridine;
at 25 ℃;
for 2h;
|
55%
|
|
With
pyridine;
|
|
|
|
|
|
With
triethylamine;
In
dichloromethane;
for 4h;
|
|
|
With
triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
|
|
|
With
triethylamine;
In
dichloromethane;
at 0 ℃;
for 1h;
|
|
|
With
triethylamine;
In
dichloromethane;
at 0 ℃;
for 1h;
|
|
|
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 12h;
Inert atmosphere;
|
|
|
With
triethylamine;
In
toluene;
at 15 - 20 ℃;
Inert atmosphere;
|
-
-
110-63-4
Butane-1,4-diol
-
-
3144-09-0
methanesulfonamide
-
-
55-98-1
busulfan
Conditions
| Conditions | Yield |
|---|---|
|
With
triethylamine;
at 5 - 40 ℃;
for 4h;
Temperature;
|
91%
|
2.What is the CAS number for Busulfan ?
The CAS number of Busulfan is 55-98-1.
More information of Busulfan 55-98-1 are:
|
CAS?Number |
55-98-1 |
|
Density |
1.35 g/cm3 |
|
Melting Point |
114-118 °C |
|
Boiling Point |
464 °C at 760 mmHg |
|
Flash Point |
234.4 °C |
|
Refractive Index |
1.5630 (estimate) |
|
HS CODE |
29053990 |
|
PSA |
103.50000 |
|
LogP |
1.88060 |
3.What are another words for Busulfan ?
Synonyms?for?Busulfan 55-98-1:1,4-Butanediol,dimethanesulfonate (8CI,9CI);Methanesulfonic acid, tetramethylene ester (6CI);1,4-Butanediol dimesylate;Busilvex;Busulphan;Citosulfan;GT 2041;GT 41;Glyzophrol;Leucosulfan;Mielevcin;Mielucin;Mileran;Misulban;Myeloleukon;Mylecytan;Sulfabutin;Tetramethylene bis[methanesulfonate];
4.What is the molecular formula of Busulfan?
The chemical formula of ?Busulfan is?C6H14O6S2 which containing 6 Carbon atoms,14 Hydrogen atoms,6 Oxygen atoms and 2 Sulfur atoms,and the molecular weight of??Busulfan?is 246.306.
5.What is Busulfan (55-98-1) used for?
Chemically, busulfan is classified as an alkyl sulfonate. One or both of the methylsulfonate ester moieties can be displaced by the nucleophilic N7 of guanine, leading to monoalkylated and cross-linked DNA. The extent of alkyl sulfonate–mediated DNA interstrand cross-linking has been shown to vary with the length of the alkyl chain between sulfonate esters, with the tetramethylene-containing busulfan showing less interstrand cross-linking capability than hexamethylene, methylene, or octamethylene analogues. Intrastrand cross-linking also occurs, preferentially at 5′-GA-3′ but also at 5′-GG-3′ sequences. Alkylation of Cys sulfhydryl groups is yet another mechanism of cytotoxicity.
InChI:InChI=1/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3
Relevant articles related to Busulfan:
|
Article |
Source |
|
BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME |
- Paragraph 00357-00361, (2015/06/11) |
|
PROCESS FOR PRODUCTION OF BIS-QUATERNARY AMMONIUM SALT, AND NOVEL INTERMEDIATE |
- Page/Page column 16, (2012/06/01) |
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